사람 구강암세포 KB에서 bavachin에 의한 세포성장 억제
Cell growth inhibition by bavachin in KB human oral cancer cells
박병수, 김진수, 고대산, 김수관, 오지수, 서요섭, 김춘성, 김도경,
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박병수 ( Park Byung-Soo ) - 조선대학교 치과대학 구강생물학연구소
김진수 ( Kim Jin-Soo ) - 조선대학교 치과대학 구강생물학연구소
고대산 ( Go Dae-San ) - 조선대학교 치과대학 구강생물학연구소
김수관 ( Kim Su-Gwan ) - 조선대학교 치과대학 구강생물학연구소
오지수 ( Oh Ji-Su ) - 조선대학교 치과대학 구강생물학연구소
서요섭 ( Seo Yo-Seob ) - 조선대학교 치과대학 구강생물학연구소
김춘성 ( Kim Chun-Sung ) - 조선대학교 치과대학 구강생물학연구소
김도경 ( Kim Do-Kyung ) - 조선대학교 치과대학 구강생물학연구소
KMID : 0353320150390010039
Abstract
Psoralea corylifolia is widely distributed over southeastern Asian countries and has been used in traditional Chinese medicine. Bavachin, one of the main constituents of P. corylifolia, possesses various biological activities such as inhibition of platelet aggregation, anti-oxidation, and anti-bacterial activity. However, the anti-cancer activity of bavachin has not yet been well defined. In this study, the cytotoxic activity of bavachin and its mechanism of cell death were examined in KB human oral cancer cells. Treatment of KB cells with bavachin cells induced inhibition of cell growth in a concentration- and a time-dependent manner as determined by MTT assay. Treatment with bavachin induced nuclear condensation and DNA fragmentation in KB cells. Proteolytic processing of caspases-3, -7, -8, and -9 was elevated by bavachin treatment in KB cells. These results suggest that bavachin can induce suppression of cell growth and cell apoptosis in KB human oral cancer cells, and thus it may have potential effects for anti-cancer drug discovery.
키워드
Cancer therapy; Apoptosis; Bavachin; Cell death; Oral cancer
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